Urinary matrix metalloproteinase-7 is a sensitive biomarker to evaluate renal tubular injury in patients with minimal change disease and focal segmental glomerulosclerosis

Abstract Objective To explore the advantages of urinary matrix metalloproteinase-7 (MMP-7) in evaluating renal tubular injury minimal change disease (MCD) and focal segmental glomerulosclerosis (FSGS) patients compared with cystatin C (CysC) retinol binding protein (RBP). Methods Serum urine samples were collected from 20 healthy volunteers, 40 MCD FSGS patients. MMP-7 levels measured by enzyme-linked immunosorbent assay (ELISA). Urinary total (UTP), CysC RBP automatic specific analyzer creatinine (Cr) level for calibration. The tissue serial sections stained immunohistochemistry periodic acid-Schiff. Results Under light microscopy, granular weak positive expression was showed sporadically cytoplasm a few epithelial cells without obvious morphological changes patients, observed some There no significant difference serum among three groups. Compared control group, higher, but not increased significantly. group MMP-7, upregulated Conclusions could only evaluate mild massive proteinuria, also continuous